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Drugmaker Gilead Sees Stocks Drop As HHS Mulls Spending Cuts On AIDS Prevention
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Gilead slips after sales miss

Sales for Biktarvy, Gilead’s blockbuster HIV drug, increased 7% year over year but missed analyst expectations.

J. Edward Moreno

Gilead Sciences slipped 3% in after-hours trading after it reported sales that missed Wall Street estimates, though earnings came in better than expected.

The company reported $6.7 billion in sales, compared to the $6.8 billion analysts were penciling in. But it also posted adjusted earnings per share of $1.81, more than the $1.78 analysts polled by FactSet were expecting.

The company, which specializes in HIV treatments and manufactures some of its bestselling drugs in Ireland, faces headwinds along with the rest of the industry as the Trump administration has cut research spending and threatened to impose tariffs on pharmaceuticals.

Gilead sold $3.1 billion in Biktarvy, its blockbuster HIV drug, which is a 7% increase year over year but less than the $3.2 billion analysts expected. Its second-highest-selling drug — Descovy, an HIV prevention treatment — brought in $586 million in sales, more than the $515 million analysts anticipated.

Gilead’s brands for PrEP — or pre-exposure prophylaxis, a type of drug that prevents HIV in high-risk patients — have grown less lucrative since its first-generation drug, Truvada, had its patent expire in 2020. Descovy, a newer and safer version of the same treatment, has become more popular but is sold at a lower price because of competition with Truvada’s generic alternative.

Gilead is expecting some growth in the second half of 2025, as one of its HIV treatments is expected to get Food and Drug Administration approval to be used as PrEP. Sunleca, the brand name for lenacapavir, was initially approved to treat HIV in patients who are already positive, but studies have shown that it can also serve as PrEP administered through biannual jabs. The only other injectable — Apretude, sold by ViiV Healthcare — is administered every two months.

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Arista Networks Reports Q3 Earnings

Arista Networks beats expectations, but stock dives on mediocre guidance

All those data centers are going to need a lot of switches and routers as well as GPUs.

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AMD posts top and bottom line beat in Q3 with Q4 sales guidance ahead of estimates

Advanced Micro Devices reported third-quarter results that exceeded analysts’ expectations on the top and bottom lines, with guidance to match.

  • Adjusted diluted earnings per share: $1.20 (estimate: $1.17)

  • Revenue: $9.25 billion (estimate: $8.74 billion, guidance for $8.4 billion to $9 billion)

  • Data center revenue: $4.34 billion (estimate: $4.14 billion)

  • Adjusted gross margin: 54% (estimate: 54%, guidance for 54%)

Its Q4 guidance for sales of $9.3 to $9.9 billion was strong relative to the anticipated $9.2 billion, while its adjusted gross margin outlook of 54.5% is bang in line with estimates.

Even so, shares are off about 2% in after-hours trading as of 4:24 p.m. ET.

“AMD's strong 3Q sales beat and 4Q outlook were likely driven by stronger PC and server CPU demand — similar to Intel's results — along with continued share gains,” write Bloomberg Intelligence analysts Kunjan Sobhani and Oscar Hernandez Tejada. “The GPU ramp-up remains ahead of expectations, aided by a gaming rebound.”

AMD has had a high-profile Q4 so far, striking a megadeal with OpenAI that its CFO said “is expected to deliver tens of billions of dollars in revenue.” That announcement prompted more than 20 price target hikes from Wall Street analysts in a 24-hour span.

The company followed that up with a pact with Oracle, which said it would deploy 50,000 of AMD’s new flagship chips in data centers starting in the second half of next year. On the upcoming conference call, the Street will be looking for as much color as possible on the sales outlook for those MI450 chips.

Ahead of this release, Morgan Stanley analyst Joseph Moore wrote:

The focus should remain on MI450. AMD's rack scale solution shipping next year is the key, and we are excited to see what the company can do. It's still early to make market share assessments, and while the Open AI agreement is clearly an accelerant, the reliance on cloud providers to ramp those 6 gigawatts still creates some uncertainty. Ultimately, to drive share gains, the company will need to provide better ROI than NVIDIA can offer, and customers still raise questions about that given lower rack density and the need to resolve ecosystem issues.

The chip designer was the third-best performing member of the VanEck Semiconductor ETF in 2025 heading into this report, with shares having more than doubled year to date.

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