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String of acquisitions fuels biotech optimism

In the past month, the S&P Biotech ETF surpassed March 2020 levels.

After nearly five years in the doldrums, a string of recent Big Pharma acquisition announcements has fueled a rally in biotech stocks.

Because biotechs often have no revenues and use borrowed money to develop new, potentially lucrative treatments for diseases, the stocks tend to shoot up when one of two things happens: they report encouraging trial results, or they are acquired by a large drugmaker. Lately, the latter has been dominating headlines in the sector.

Pfizer announced last month that it would acquire obesity startup Metsera for $7.3 billion. Last week, Novo Nordisk announced that it was buying up Akero Therapeutics, which is working on liver disease treatments, for up to $5.2 billion. Johnson & Johnson is in talks to buy Protagonist Therapeutics, The Wall Street Journal reported Friday.

The SPDR S&P Biotech ETF surpassed its March 2020 levels last month and has continued to climb higher. It is now up more than 15% for the year, outperforming both the Russell 2000 and S&P 500.

Investors poured money into biotechs in 2020 as the COVID-19 pandemic hit. Many of those companies did not deliver on the treatments they were developing, and faced with rising inflation, the Federal Reserve began hiking interest rates in 2022.

Now, interest rates are coming down and Big Pharma has gained more regulatory clarity, which may put companies in a better position to acquire biotechs. Many large drugmakers are also facing a patent cliff, which increases pressure to add new drugs to their portfolio.

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United Airlines rallies after Q4 earnings and Q1 profit guidance top estimates

Shares of United Airlines are rising after the bell on Tuesday, following the release of the carrier’s fourth-quarter and full-year earnings report.

United posted adjusted earnings per share of $3.10 in Q4, above the $2.92 per share expected by Wall Street analysts polled by Bloomberg. Sales of $15.4 billion were roughly in line with the consensus estimate.

The airline also:

  • Forecast full-year earnings per share between $12 and $14, bracketing Wall Street’s call for $13.04. For Q1, management sees EPS between $1.00 and $1.50, the midpoint of which is above the $1.16 expected by Wall Street.

  • Booked $13.93 billion in passenger revenue on the quarter, up nearly 5% year over year.

“Strong revenue momentum has continued into 2026,” according the company’s press release. “The week ending January 4th was the highest flown revenue week in United history, and the week ending January 11th was the highest ticketing week and the highest week for business sales in United history.”

UAL’s premium ticket revenue climbed 9% compared to a 7% increase in basic economy revenue. The “K-shaped economy” has become increasingly visible in travel trends at major US airlines. Last week, Delta’s revenue from first-class and business passengers eclipsed its main cabin revenue for the first time.

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POET Technologies nears multiyear high on strong call demand after flagship product wins award

POET Technologies is surging on heavy volumes and high call demand after announcing that it won a Product Innovation Award at China’s Infostone awards.

The honor went to the optical communications company’s flagship product, the Teralight, which uses light to move data between chips.

“Unveiled less than a year ago at the 2025 OFC Conference, POET Teralight has driven commercial interest in the Company because of its highly integrated design and complete optical system-on-chip architecture that simplifies module development,” per the press release.

This award may be the latest excuse to buy the stock, which is up over 40% year to date.

Call activity is elevated, with nearly 37,000 having changed hands as of 10:55 a.m. ET, well above the 20-day average of 28,030 for a full session. Shares are approaching their multi-year high of $9.41.

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