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Still life of a bottle of the new Wegovy semaglutide tablets on a womans hand.
(Michael Siluk/UCG/Universal Images Group via Getty Images)
GLUTIDE TURNED

Novo Nordisk has lost most of its post-Wegovy market cap gains

A weak sales outlook and a copycat scare capped a brutal week for Europe’s one-time most valuable company.

Hyunsoo Rim

Danish pharma giant Novo Nordisk has now erased nearly all of the market cap gains it racked up after winning FDA approval for its weight-loss drug Wegovy in 2021.

The company’s shares slid ~20% last week amid two major setbacks. On Tuesday, Novo warned that 2026 sales could fall by as much as 13%, citing “unprecedented pricing pressure” in the US, intensifying competition, and a looming patent expiry for semaglutide, the active ingredient in its GLP-1 drugs.

Then, telehealth company Hims & Hers launched a copycat version of Novo’s newly approved Wegovy pill on Thursday at an initial price of just $49 a month... though later that day, the FDA warned of a crackdown on “illegal copycat drugs.” Hims pulled the pill on Saturday. Novo’s shares were higher this morning as the company announced that it’s suing Hims.

Even so, the hits wiped out Novo’s January rebound, fueled by excitement around its oral pill launch. Zoom out further and the picture is even starker: almost all of Novo’s gains since Wegovy burst onto the scene are now gone.

Since its FDA approval in June 2021, Wegovy, alongside its diabetes-treating counterpart Ozempic, helped propel Novo to become Europe’s most valuable company, with its market cap peaking at ~$650 billion in mid-2024.

But that dominance didn’t last. Shortages of semaglutide left room for cheaper compounded alternatives from companies like Hims. Meanwhile, competitor Eli Lilly surged ahead after launching its weight-loss drug Zepbound in late 2023 — momentum that briefly pushed Lilly’s valuation above $1 trillion last November. By contrast with Novo, Lilly posted stronger-than-expected 2026 guidance last week, as its GLP-1s have been more effective than Novo's offerings, while also being cost-competitive.

After the weight-loss saga’s dramatic turn this weekend, however, Novo might still have some breathing room.

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Report: Boeing could unveil 500-jet order from China during Trump’s visit later this month

Shares of Boeing are up nearly 4% on Friday afternoon, following a Bloomberg report that the company could be close to finalizing a deal to sell 500 planes to China.

The deal was first reported in August and would be one of Boeing’s largest ever.

According to Bloomberg’s sources, the deal could be officially unveiled when President Trump travels to China at the end of the month. That trip could be delayed given the war in Iran. The deal, sources say, could still fall apart — similar language to when it was first reported on more than six months ago.

Boeing has been on the outside of the Chinese market, in terms of new orders, since 2019 amid escalating US-China trade tensions.

According to Bloomberg’s sources, the deal could be officially unveiled when President Trump travels to China at the end of the month. That trip could be delayed given the war in Iran. The deal, sources say, could still fall apart — similar language to when it was first reported on more than six months ago.

Boeing has been on the outside of the Chinese market, in terms of new orders, since 2019 amid escalating US-China trade tensions.

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Why software shares are withstanding the war jitters

The outbreak of the war in Iran has clearly rattled investors and created a few clear winners — mostly energy stocks — and losers — consumer staples, airlines, and, well, more or else everything else.

But there is one interesting outlier to that Manichaean market dynamic.

Software shares — often the same companies that the market was giving up for dead just a few weeks ago due to overexpectations of an AI-driven disruption — have been holding up remarkably well.

These companies, including Intuit, ServiceNow, Datadog, Snowflake, IBM, Workday, and Oracle, have actually had a pretty decent run since the war started with a combined US-Israeli attack on Iran last weekend.

A new note from RBC Capital’s Rishi Jaluria suggests this isn’t just a fluke. Looking at the performance of software stocks during periods of geopolitical stress and market volatility over the last 10 and 25 years, his team found that software shares appear fairly well insulated when these broader shocks hit. RBC wrote:

“The defensive nature of SaaS models and the mission-critical nature of many core software systems at the enterprise level (e.g., in the absence of mass layoffs that may create seat-based headwinds, geopolitical uncertainty and/or market volatility typically will not cause an enterprise CIO to consider ripping out their ERP, CRM, Cyber systems, etc.”

I briefly got Jaluria on the phone yesterday, and he explained a bit more about why he thinks investors might see software as a decent place to hide out from the current chaos.

“With everything in the Middle East, you have to think about not just oil and gas input prices but also supply chains,” he said. “With software, you’re not really thinking about that.”

In other words, there is no equivalent of a closure of the Strait of Hormuz that software investors have to worry about.

Others suggested that the near-term profitability of these giant software companies — aside from concerns about potential long-term disruption from AI — may look different in the face of the economic uncertainty that seems to be growing with the war, especially after a sell-off that has left them relatively attractively valued.

Mark Moerdler, who covers software stocks for Bernstein Research, says that while the AI worries are clearly real, software companies continue to be highly productive cash cows.

“Everyone is afraid that AI is a massive disruptor, and all these articles you read talk about AI as massive disruptor or the world is ending or whatever,” he said. “You don’t see it in the fundamental numbers of the companies I cover. They are delivering GAAP profits, free cash flow, and they’re good investment ideas.”

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