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Eli Lilly tumbles after selling way fewer weight-loss drugs than expected

Shares of Eli Lilly are tumbling after sales of its well-known GLP-1 weight-loss drugs massively undershot Wall Street’s expectations in the fourth quarter.

The company said on Monday that it made approximately $1.9 billion selling Zepbound and $3.5 billion selling Mounjaro in the final quarter of 2024. Analysts polled by FactSet estimated $2.1 billion for Zepbound and $4.4 billion for Mounjaro. 

Both are the same drug (tirzepatide), but Mounjaro is the brand name approved to treat diabetes and Zepbound can be prescribed for a wider range of conditions.

Eli Lilly has struggled to keep up with high demand for its weight-loss drugs. For a chunk of 2024, these drugs were considered in shortage by the US Food and Drug Administration, which allowed copycat compound versions to be sold by companies like Hims & Hers.

“We continued to make progress on our manufacturing build-out, and U.S. supply across all doses of tirzepatide was available throughout Q4,” Eli Lilly CEO David A. Ricks said in a statement. “The rest of our medicines performed within our expectations.”

Ozempic and Wegovy, two other popular GLP-1 weight-loss drugs made by Novo Nordisk, have also faced shortages and have flattened in recent quarters.

Both are the same drug (tirzepatide), but Mounjaro is the brand name approved to treat diabetes and Zepbound can be prescribed for a wider range of conditions.

Eli Lilly has struggled to keep up with high demand for its weight-loss drugs. For a chunk of 2024, these drugs were considered in shortage by the US Food and Drug Administration, which allowed copycat compound versions to be sold by companies like Hims & Hers.

“We continued to make progress on our manufacturing build-out, and U.S. supply across all doses of tirzepatide was available throughout Q4,” Eli Lilly CEO David A. Ricks said in a statement. “The rest of our medicines performed within our expectations.”

Ozempic and Wegovy, two other popular GLP-1 weight-loss drugs made by Novo Nordisk, have also faced shortages and have flattened in recent quarters.

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OpenAI’s ARR reached over $20 billion in 2025, CFO says

Sam Altman’s $500 billion artificial intelligence behemoth hit a major financial milestone last year, according to a new blog post over the weekend from OpenAI CFO Sarah Friar, as the company confirmed it had hit a more than $20 billion annual revenue run rate at the end of 2025.

Elsewhere in the blog post, Friar spent time addressing the company’s shifting goals, referencing plans to “close the distance between where intelligence is advancing and how individuals, companies, and countries actually adopt and use it.” As has become customary in the AI company press release genre, the CFO was also keen to tout the unending growth of the business, writing:

  • Both our Weekly Active User (WAU) and Daily Active User (DAU) figures continue to produce all-time highs. This growth is driven by a flywheel across compute, frontier research, products, and monetization.

  • Compute grew 3X year over year or 9.5X from 2023 to 2025: 0.2 GW in 2023, 0.6 GW in 2024, and ~1.9 GW in 2025.

And, perhaps most importantly for current backers and those keeping an eye on the private company before its rumored mega IPO:

  • Revenue followed the same curve growing 3X year over year, or 10X from 2023 to 2025: $2B ARR in 2023, $6B in 2024, and $20B+ in 2025. This is never-before-seen growth at such scale.

That latest figure has certainly set tongues in the tech world wagging, just as the company announced it would begin rolling out ads to free and ChatGPT Go users. It also puts the chatbot giant a fair way ahead of competitors like Anthropic, the company behind Claude.

OpenAI Anthropic ARR race
Sherwood News

Elsewhere in the blog post, Friar spent time addressing the company’s shifting goals, referencing plans to “close the distance between where intelligence is advancing and how individuals, companies, and countries actually adopt and use it.” As has become customary in the AI company press release genre, the CFO was also keen to tout the unending growth of the business, writing:

  • Both our Weekly Active User (WAU) and Daily Active User (DAU) figures continue to produce all-time highs. This growth is driven by a flywheel across compute, frontier research, products, and monetization.

  • Compute grew 3X year over year or 9.5X from 2023 to 2025: 0.2 GW in 2023, 0.6 GW in 2024, and ~1.9 GW in 2025.

And, perhaps most importantly for current backers and those keeping an eye on the private company before its rumored mega IPO:

  • Revenue followed the same curve growing 3X year over year, or 10X from 2023 to 2025: $2B ARR in 2023, $6B in 2024, and $20B+ in 2025. This is never-before-seen growth at such scale.

That latest figure has certainly set tongues in the tech world wagging, just as the company announced it would begin rolling out ads to free and ChatGPT Go users. It also puts the chatbot giant a fair way ahead of competitors like Anthropic, the company behind Claude.

OpenAI Anthropic ARR race
Sherwood News

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