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Novo Nordisk stock is making serious gains after latest GLP-1 trial, which could be even better than Wegovy

Shares of Novo Nordisk surged ~11% on Friday morning after the Wegovy and Ozempic maker announced promising trial results of its experimental weight-loss drug, amycretin.

Patients in the trial lost 9.7% of their body weight after 20 weeks on the lowest dose, and as much as 22% after 36 weeks on the highest dose, according to the company.

While Wegovy only mimics the gut hormone GLP-1 to suppress appetite, amycretin combines GLP-1 with another hunger-regulating hormone, amylin, further enhancing the effect. Patients on the highest dose of amycretin lost up to 13% of their weight over 12 weeks, compared to around 6% for Wegovy users in the same time frame.

The Danish pharma giant’s progress comes amid growing competition from Eli Lilly, which says its obesity drug, Zepbound, offers 47% greater weight loss than Wegovy. Novo’s shares also took a hit last month when disappointing trial results of its next-gen obesity drug, CagriSema, sent its stock tumbling over 20% in a single day.

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SpaceX gets a wave of bullish ratings from Wall Street analysts

SpaceX received more than a dozen positive analyst calls on Tuesday — including from major Wall Street banks — as they initiate coverage on Elon Musk’s space and AI company.

SpaceX went public on June 12 at a $2.2 trillion valuation, the largest debut in history. While the company hasn’t yet posted a profit, it seems to have convinced Wall Street that it will get there and grow its valuation on the way.

Of the at least 17 analysts that gave a rating on Tuesday, all but one gave it a “buy” or “outperform” rating. MoffettNathanson was "neutral."

The ratings come as SpaceX joined the Nasdaq 100 index, a benchmark tech-heavy basket of companies that underpins millions of portfolios. The inclusion adds built-in demand for the stock from index funds and ETFs.

Still, SpaceX fell more than 5% on Tuesday amid a broader sell-off, and is currently effectively flat from its opening price of $150 a share.

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Nike sinks to lowest level since 2014 after warning of “challenged” sales environment in Q4 report

Did Nike do it?

Investors had a mixed reaction after the global sports apparel company reported its fourth quarter earnings on Tuesday after the bell. Shares initially rose 5% as Nike beat out Wall Street expectations amid a hefty tariff refund bonus. However, the stock then sank to its lowest level since August 2014 in postmarket trading.

Here are the Q4 numbers:

  • Revenue of $11.0 billion (estimate: $10.8 billion).

  • Adjusted earnings per share of $0.20 (estimate: $0.12).

Ahead of this report, Nike warned that results would be flattered by a one-time tariff refund (now estimated at roughly $0.52 per share for the bottom line). That gave the company an extra cushion in snapping its streak of seven quarters of year-over-year profit declines.

Over the past year, the company had been punished by tariffs on imported goods, stagnant consumer spending, and increasing competition from other footwear brands like New Balance, Adidas, and Hoka.

Outgoing CFO Matthew Friend deemed it an “increasingly challenging operating environment, where sell-through remains challenged.”

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